Nanoscience is the emerging science of objects that are intermediate in size between the largest molecules and the smallest structures that can be fabricated by current photolithography; that is, the science of objects with smallest dimensions ranging from a few nanometers to less than 100 nanometers.[1–3] In chemistry, this range of sizes has historically been associated with colloids, micelles, polymer molecules, phase-separated regions in block copolymers, and similar structures—typically, very large molecules, or aggregates of many molecules. More recently, structures such as buckytubes, silicon nanorods, and compound semi conductor quantum dots have emerged as particularly interesting classes of nanostructures. In physics and electrical engineering, nanoscience is most often associated with quantum behavior, and the behavior of electrons and photons in nanoscale structures. Biology and biochemistry also have a deep interest in nanostructures as components of the cell; many of the most interesting structures in biology—from DNA and viruses to subcellular organelles and gap junctions—can be considered as nanostructures.

In this type of reaction, a nucleophile reacts with haloalkane (the substrate) having a partial positive charge on the carbon atom bonded to halogen. A substitution reaction takes place and halogen atom, called leaving group departs as halide ion. Since the substitution reaction is initiated by a nucleophile, it is called nucleophilic substitution reaction

Path Limitations There are three requirements for the S N 2 reaction. In order to be pushed out, the leaving group must be at least fair, usually good. The nucleophile also must be reactive enough to push out the leaving group. Finally, the back side of the tetrahedral carbon attacked must be accessible to the nucleophile and not blocked by other groups.

The hydroxide ion is a good nucleophile since the oxygen atom has a negative charge and a pair of unshared electrons. The carbon atom is electrophilic since it is bound to a (more electronegative) halogen, which pulls electron density away from the carbon, thus polarizing the bond with carbon bearing partial positive charge and the halogen bearing partial negative charge. The nucleophile is attracted to the electrophile by electrostatic charges. The nucleophile attacks the electrophilic carbon through donation of 2 electrons. Carbon can only have a maximum of 8 valence electrons, so as the carbon nucleophile bond is forming, then the carbon-leaving group bond must be breaking. Iodide is the leaving group since it leaves with the pair of electrons that once bound it to carbon.

Ante-mortem Inspection • This is the comprehensive examination of food animals destined to slaughter • Conducted in the Lairage within 24 hours of slaughter and repeated if slaughter has been delayed over a day • Done by an official veterinarian in the slaughter house • In some cases it can be done on the farm if legislation allows. E.g., pigs and poultry • The slaughterhouse layout and conditions must facilitate the ante-mortem inspections, so that each animal can be readily checked and identified. • Adequate lighting and separate pens for sick or suspect animals are necessary

Post Mortem Examination • Post Mortem Inspection - examination of carcasses and organs after slaughter to assess whether these products are fit for human consumption • Edible products - fit for human consumption; includes meat, certain offal, casing etc. from animals which have been examined and passed by an inspector • Inedible products - meat products which are not fit for human consumption e.g. horn, hair, bone, bristle, blood • Condemned meat - meat and meat products which have been found by an inspector not to be fit for human consumption. Includes diseased and defective carcasses or part of carcasses and severely contaminated products

Enzymes Enzymes are biocatalysts the catalysts of life. A catalyst is defined as a substance that increases the velocity or rate of a chemical reaction without itself undergoing any change in the overall process. Enzymes may be defined as biocatalysts synthesized by living cells. Their basic properties include, They are protein in nature (exception - RNA acting as ribozyme), colloidal and thermolabile in character, and specific in their action. In the laboratory, hydrolysis of proteins by a strong acid at 100oC takes at least a couple of days. The same protein is fully digested by the enzymes in gastrointestinal tract at body temperature (37oC) within a couple of hours. This remarkable difference in the chemical reactions taking place in the living system is exclusively due to enzymes. The very existence of life is unimaginable without the presence of enzymes. Enzymes catalyse a specific substance called a substrate. Role of enzymes in biochemical reactions Enzymes are biological catalysts that increase the rate or velocity, v, of many physiologic reactions yet are not used up in the reaction and are synthesized by living cells. Enzymes are specialized proteins found and produced by living cells and act as biological catalysts a. In the absence of enzymes, most reactions in the body would proceed so slowly that life would be impossible. Some chemical reactions are only possible by enzymes. C. A deficiency in enzyme activity can cause disease. a. Inherited absence or mutations in enzymes involved in critical metabolic pathways e.g. the urea cycle or glycogen metabolism are referred to as inborn errors of metabolism. If not detected soon after birth, these conditions can lead to serious metabolic derangements in infants and even death. b. An enzyme deficiency can produce a deficiency of the product of the reaction it catalyzes, which may inhibit other reactions that depend on availability of that product. c. Accumulation of the substrate or metabolic byproducts of the substrate due to an enzyme deficiency can have profound physiologic consequences. d. Most inborn errors of metabolism manifest after birth because the exchange of metabolites between mother and fetus provides for fetal metabolic needs in utero. e. Therapeutic strategies for enzyme deficiency diseases include dietary modification and potential gene therapy or direct enzyme replacement

This is notes for first years sem 1 notes. They are very elaborative and wide based notes on matters of BOTANY.

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The goal is for students to communicate engineering designs accurately through pictures since drawings are more effective than words alone. Precision and standardization are important for manufacturing.

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To help learners understand and appreciate the importance of economics national activities

To expose students to cooperative and microfinance activities

A complete handbook on WIPO's IP policy, law and use guidelines.

A full dive-in for an understanding of criminal litigation practice and procedure.

Summary of concepts in cellular basis of life

Comprehensive notes on fundamentals of entomology.