PATHOLOGY
| Institution | University of Nairobi |
| Course | MBCHB |
| Year | 6th Year |
| Semester | Unknown |
| Posted By | Edgar Dishon Abonyo |
| File Type | ppt |
| Pages | |
| File Size | 2.01 MB |
| Views | 482 |
| Downloads | 0 |
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Description
Oncology emergencies are urgent medical situations that arise in cancer patients, often requiring immediate intervention.
Types of Emergencies:
Tumor Lysis Syndrome (TLS):
Occurs due to rapid cell destruction, leading to metabolic imbalances.
Hypercalcemia:
Elevated calcium levels can cause confusion, dehydration, and cardiac issues.
Spinal Cord Compression:
Results from tumor pressure on the spinal cord, leading to neurological deficits.
Superior Vena Cava Syndrome:
Obstruction of blood flow in the superior vena cava, causing swelling and respiratory distress.
Febrile Neutropenia:
Fever in patients with low white blood cell counts, indicating possible infection.
Management:
Prompt recognition and treatment are critical to prevent complications and improve outcomes.
Interventions may include hydration, medications, radiation, or surgical procedures depending on the emergency.
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PATHOLOGY
Cancer is a significant public health issue in Kenya, with rising incidence and mortality rates.
Key Statistics:
Breast, cervical, and prostate cancers are the most prevalent types.
Increasing cases attributed to lifestyle changes, environmental factors, and improved diagnostic capabilities.
Challenges:
Limited access to early detection and treatment facilities, particularly in rural areas.
Inadequate healthcare infrastructure and a shortage of trained oncology professionals.
Initiatives:
Government and non-governmental organizations are implementing awareness campaigns and screening programs.
Efforts to improve treatment access through the establishment of specialized cancer centers and palliative care services.
Future Directions:
Emphasis on research, prevention strategies, and enhancing healthcare systems to address the growing cancer burden.
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PATHOLOGY
Cancer treatment varies based on the type, stage, and location of cancer, as well as the patient's overall health. The main treatment modalities include:
1. Surgery
Purpose: Remove the tumor and surrounding tissue.
Types:
Curative surgery (to remove cancer completely).
Palliative surgery (to relieve symptoms).
2. Radiation Therapy
Purpose: Use high-energy particles or waves to destroy or damage cancer cells.
Types:
External beam radiation (from outside the body).
Internal radiation (brachytherapy).
3. Chemotherapy
Purpose: Use of drugs to kill cancer cells or stop their growth.
Administration: Can be given orally, intravenously, or via injection.
Side Effects: Nausea, fatigue, hair loss, etc.
4. Immunotherapy
Purpose: Boost the body’s natural defenses to fight cancer.
Types:
Monoclonal antibodies.
Immune checkpoint inhibitors.
5. Targeted Therapy
Purpose: Target specific molecules involved in cancer growth and progression.
Examples: Tyrosine kinase inhibitors, PARP inhibitors.
6. Hormone Therapy
Purpose: Block or lower the amount of hormones in the body to slow or stop the growth of cancer.
Used for: Hormone-sensitive cancers (e.g., breast and prostate cancer).
7. Stem Cell Transplant
Purpose: Replace damaged bone marrow with healthy stem cells.
Used for: Certain types of blood cancers (e.g., leukemia, lymphoma).
Conclusion
Cancer treatment is often a combination of these modalities, tailored to the individual patient's needs. Ongoing research and clinical trials continue to improve treatment options and outcomes.
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